据6月18日的《科学》杂志报道，通过对香港一家屠宰场中的猪只进行监控，研究人员发现，从2009年开始的大流行性的H1N1流感病毒在过去的一年半中在猪的体内进行了基因的重组。这一发现令研究人员感到担心，因为这种基因的进一步的“重新排布”可能最终会产生出又一种对人有害的流感病毒株。 因为这个原因，Dhanasekaran Vijaykrishna及其同僚指出，应该加强对全球猪支的监控。
在一篇Brevium中，这些研究人员讲述了他们是如何在今年1月发现H1N1病毒的一种新的基因重组，并在对其分析后证实了它起源于H1N1/2009病毒。他们提出，H1N1/2009病毒重新介入到猪的体内使得该病毒能够进行其基因重组。
他们警告说，这种2010H1N1病毒会在猪体内做进一步的基因重组，并变得对人有危险。Vijaykrishna及其同僚呼吁对在新的病毒株中所发现的8个H1流感基因做全面的特征鉴定，这样，未来的基因重组事件可被人们快速地识别和确定。
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Science DOI: 10.1126/science.1189132
Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
D. Vijaykrishna,1,2,*, L. L. M. Poon,1,* H. C. Zhu,1,2 S. K. Ma,1 O. T. W. Li,1 C. L. Cheung,1 G. J. D. Smith,1,2, J. S. M. Peiris,1, Y. Guan1,2,
The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.
1 State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
2 International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong 515031, China.
